From the direction of Shanghai:
Take the Shanghai-Nanjing High-speed Road to the Yangzhou-Liyang High-speed Road, and then take that to Yangzhou.
Tip: The Yangzhou-Liyang High-speed Road has two exits: the north one leading to Slender West Lake, and the south one to the Living Mall.
Take the Shanghai-Nanjing High-speed Road to Zhenjiang, then take the Ningbo-Nantong High-speed Road to the Jiangwang Exit.
Take the Shanghai-Nanjing High-speed Road to Wuxi, then the Beijing-Shanghai High-speed Road to the Yangzhou exit. At the Jiangduzhuan Bridge Toll Station, change to the Ningbo-Nantong High-speed Road to proceed to the downtown area of Yangzhou.
From the direction of Nanjing:
Enter the Ningbo-Nantong High-speed Road at the Nanjing Second Bridge, and drive until the Jiangwang Exit.
From the direction of Beijing:
Drive south on the Beijing-Shanghai High-speed Road, go through Tianjin, Jinan of Shandong province, and Huai'an of Jiangsu province, then change to the Qidong-Yangzhou High-speed Road, finally take the Slender West Lake exit to enter the downtown area of Yangzhou.